Please use this identifier to cite or link to this item: http://dx.doi.org/10.18419/opus-1937
Authors: Winterhager, Elke
Brümmer, Franz
Dermietzel, Rolf
Hülser, Dieter F.
Denker, Hans-Werner
Title: Gap junction formation in rabbit uterine epithelium in response to embryo recognition
Issue Date: 1988
metadata.ubs.publikation.typ: Zeitschriftenartikel
metadata.ubs.publikation.source: Developmental biology 126 (1988), S. 203-211. URL http://dx.doi.org./10.1016/0012-1606(88)90254-0
URI: http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-68698
http://elib.uni-stuttgart.de/handle/11682/1954
http://dx.doi.org/10.18419/opus-1937
Abstract: Gap junction formation was studied in the uterine epithelium of nonpregnant, pregnant, and pseudopregnant rabbits in the periimplantation phase (6, 7, 8 days post coitum/post human gonadotropin injection) using freeze-fracture and immunocytochemistry as well as intracellular Lucifer yellow injection. At implantation (7 days post coitum) the uterine epithelial cells of the implantation chamber become junctionally coupled as evidenced by all three methods used. Gap junction protein (26K) becomes detectable immunocytochemically with a monoclonal antibody at 6 days post coitum in the epithelium surrounding the blastocyst, i.e., in the forming implantation chamber. The same sequence of events, starting with the presence of the gap junction protein before cell-to-cell coupling becomes evident, was observed in the blastocyst-free segments 1 day later. In contrast, uterine epithelium of nonpregnant and pseudopregnant animals in comparable phases shows an extremely low degree of coupling. The presence of the blastocyst is a necessary condition for the induction of gap junctions as demonstrated by unilateral pregnancy produced by tubal ligation. Thus, gap junction formation is one of the first maternal responses to a locally acting signal of the blastocyst.
Appears in Collections:04 Fakultät Energie-, Verfahrens- und Biotechnik

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