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Authors: Brümmer, Franz
Zempel, Günther
Bühle, Peter
Stein, Johannes-Christoph
Hülser, Dieter F.
Title: Retinoic acid modulates gap junctional permeability: a comparative study of dye spreading and ionic coupling in cultured cells
Issue Date: 1991 Zeitschriftenartikel Experimental cell research 196 (1991), S. 158-163. URL
Abstract: All-trans retinoic acid (RA), which was recently identified as a morphogen, affects gap junctional permeability in a dose- and time-dependent manner. In five different established mammalian cell lines (FL, BRL, BICR/M1Rk, HEL37, BT5C1) 100 μmol/liter RA reduced Lucifer yellow spreading within 30 min to 20-50% of the control. Ionic coupling, however, remained almost unaffected under the same conditions. Freezefractured membranes of untreated and RA-treated cells were similar with regard to frequency and sizes of gap junction plaques. With concentrations of less than 10 μmol/liter RA the dye spreading increased significantly in the human amniotic cell line FL, pointing to a possible modulatory effect of RA on junctional communication.
Appears in Collections:04 Fakultät Energie-, Verfahrens- und Biotechnik

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