Bitte benutzen Sie diese Kennung, um auf die Ressource zu verweisen:
http://dx.doi.org/10.18419/opus-1954
Langanzeige der Metadaten
DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Bräuner, Thomas | de |
dc.contributor.author | Hülser, Dieter F. | de |
dc.date.accessioned | 2011-11-21 | de |
dc.date.accessioned | 2016-03-31T07:53:03Z | - |
dc.date.available | 2011-11-21 | de |
dc.date.available | 2016-03-31T07:53:03Z | - |
dc.date.issued | 1990 | de |
dc.identifier.other | 368441962 | de |
dc.identifier.uri | http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-68828 | de |
dc.identifier.uri | http://elib.uni-stuttgart.de/handle/11682/1971 | - |
dc.identifier.uri | http://dx.doi.org/10.18419/opus-1954 | - |
dc.description.abstract | The invasive behavior of five tumor cell lines was investigated with an in vitro invasion assay developed by Mareel et al. Spheroids of all 5 cell lines readily attached to precultured heart fragments (PHF), resulting in confronting pairs. Tumor cells (8ICR/MIR k C6, and EMT6/Ro) which communicated with the host tissue via gap junctions, rapidly invaded the PHF within 3 days. Population doubling time or migratory activities had no influence on the invasion process. The noncoupled HeLa and L cells formed a cellular capsule around the PHF and showed no invasive activities. HeLa cells, however, started to destroy the PHF after 4 days. We suggest a mechanism different from that of coupled tumor cells. Epithelioid HeLa cells are linked by numerous tight junctions and may, therefore, cut off the nutrition supply for the inner-laying PHF, resulting in a disintegration of the heart tissue. | en |
dc.language.iso | en | de |
dc.rights | info:eu-repo/semantics/openAccess | de |
dc.subject.classification | Gap junction , Tumor , Zellkultur | de |
dc.subject.ddc | 570 | de |
dc.title | Tumor cell invasion and gap junctional communication. 2, Normal and malignant cells confronted in multicell spheroids | en |
dc.type | article | de |
ubs.fakultaet | Fakultät Energie-, Verfahrens- und Biotechnik | de |
ubs.institut | Institut für Biomaterialien und biomolekulare Systeme | de |
ubs.opusid | 6882 | de |
ubs.publikation.source | Invasion metastasis 10 (1990), S. 31-48 | de |
ubs.publikation.typ | Zeitschriftenartikel | de |
Enthalten in den Sammlungen: | 04 Fakultät Energie-, Verfahrens- und Biotechnik |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
---|---|---|---|---|
huel63.pdf | 3,26 MB | Adobe PDF | Öffnen/Anzeigen |
Alle Ressourcen in diesem Repositorium sind urheberrechtlich geschützt.