Please use this identifier to cite or link to this item: http://dx.doi.org/10.18419/opus-1977
Authors: Hülser, Dieter F.
Brümmer, Franz
Title: Closing and opening of gap junction pores between two- and threedimensionally cultured tumor cells
Issue Date: 1982
metadata.ubs.publikation.typ: Zeitschriftenartikel
metadata.ubs.publikation.source: Biophysics of structure and mechanism 9 (1982), S. 83-88. URL http://dx.doi.org./10.1007/BF00539105
URI: http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-68589
http://elib.uni-stuttgart.de/handle/11682/1994
http://dx.doi.org/10.18419/opus-1977
Abstract: Intercellular signal transfer via gap junction pores in cultured multicell spheroids of BICR/M1R-K cells decreases with increasing spheroid age. In two days old spheroids the pores allow passage of Lucifer yellow molecules. Two days later, this fluorescent dye is retained in the injected cell even though the cells are still electrically coupled. Gap junction plaques of considerable size are still found in 9 days old spheroids, when the cells are completely uncoupled. The same cells growing as monolayer cultures do not exhibit such a gradual closing of their gap junction pores: Their coupling is established at first cell contact, probably by a gradual opening of the pores, which remain open even up to 9 days in culture.
Appears in Collections:04 Fakultät Energie-, Verfahrens- und Biotechnik

Files in This Item:
File Description SizeFormat 
huel36.pdf1,37 MBAdobe PDFView/Open


Items in OPUS are protected by copyright, with all rights reserved, unless otherwise indicated.