Please use this identifier to cite or link to this item: http://dx.doi.org/10.18419/opus-2003
Authors: Pieper, Dietmar H.
Engesser, Karl-Heinrich
Knackmuss, Hans-Joachim
Title: (+)-4-Carboxymethyl-2,4-dimethylbut-2-en-4-olide as dead-end metabolite of 2,4-dimethylphenoxyacetic acid or 2,4-dimethylphenol by alcaligenes eutrophus JMP 134
Issue Date: 1990
metadata.ubs.publikation.typ: Zeitschriftenartikel
metadata.ubs.publikation.source: Archives of microbiology 154 (1990), S. 600-604. URL http://dx.doi.org./10.1007/BF00248843
URI: http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-76288
http://elib.uni-stuttgart.de/handle/11682/2020
http://dx.doi.org/10.18419/opus-2003
Abstract: 2,4-Dimethylphenoxyacetic acid and 2,4-dimethylphenol are not growth substrates for Alcaligenes eutrophus JMP 134 although being cooxidized by 2,4-dichlorophenoxyacetate grown cells. None of the relevant catabolic pathways were induced by the dimethylphenoxyacetate, 3,5-Dimethylcatechol is not subject to metacleavage. The alternative ortho-eleavage is also unproductive and gives rise to (+)-4-carboxymethyl-2,4-dimethylbut-2-en-4-olide as a dead-end metabolite. High yields of this metabolite were obtained with the mutant Alcaligenes eutrophys JMP 134-1 which constitutively expresses the genes of 2,4-dichlorophenoxyacetic acid metabolism.
Appears in Collections:04 Fakultät Energie-, Verfahrens- und Biotechnik

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