Bitte benutzen Sie diese Kennung, um auf die Ressource zu verweisen:
http://dx.doi.org/10.18419/opus-2366
Autor(en): | Blombach, Bastian Takors, Ralf |
Titel: | CO2 - intrinsic product, essential substrate and regulatory trigger of microbial and mammalian production processes |
Erscheinungsdatum: | 2015 |
Dokumentart: | Zeitschriftenartikel |
Erschienen in: | Frontiers in bioengineering and biotechnology 3 (2015), article 108. URL http://dx.doi.org./10.3389/fbioe.2015.00108 |
URI: | http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-102414 http://elib.uni-stuttgart.de/handle/11682/2383 http://dx.doi.org/10.18419/opus-2366 |
Zusammenfassung: | Carbon dioxide formation mirrors the final carbon oxidation steps of aerobic metabolism in microbial and mammalian cells. As a consequence CO2/HCO3- dissociation equilibria arise in fermenters by the growing culture. Anaplerotic reactions make use of the abundant CO2/HCO3- levels for refueling citric acid cycle demands and for enabling oxaloacetate derived products. At the same time CO2 is released manifold in metabolic reactions via decarboxylation activity. The levels of extracellular CO2/HCO3- depend on cellular activities and physical constraints such like hydrostatic pressures, aeration and the efficiency of mixing in large-scale bioreactors. Besides, local CO2/HCO3- levels might also act as metabolic inhibitors or transcriptional effectors triggering regulatory events inside the cells. This review gives an overview about fundamental physicochemical properties of CO2/HCO3- in microbial and mammalian cultures effecting cellular physiology, production processes, metabolic activity and transcriptional regulation. |
Enthalten in den Sammlungen: | 04 Fakultät Energie-, Verfahrens- und Biotechnik |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
---|---|---|---|---|
Blombach_und_Takors_2015_CO2_intrinsic_product_essential_substrate_and_.pdf | 460,44 kB | Adobe PDF | Öffnen/Anzeigen |
Alle Ressourcen in diesem Repositorium sind urheberrechtlich geschützt.