Please use this identifier to cite or link to this item: http://dx.doi.org/10.18419/opus-6924
Authors: Schmidt, Werner J.
Bubser, Michael
Hauber, Wolfgang
Title: Behavioural pharmacology of glutamate in the basal ganglia
Issue Date: 1992
metadata.ubs.publikation.typ: Zeitschriftenartikel
metadata.ubs.publikation.source: Journal of neural transmission, Supplementum 38 (1992), S. 65-89
URI: http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-39650
http://elib.uni-stuttgart.de/handle/11682/6941
http://dx.doi.org/10.18419/opus-6924
Abstract: In Parkinson's disease the dopaminergic inhibition - mediated by DA2 receptors in the triatum - is reduced. Therefore glutamatergic excitation predominates in the antero-dorsal striatum. In turn the glutamatergic neurons of the subthalamic nucleus become disinhibited. Antagonists of the NMDAsubtype of glutamate receptor injected locally into the glutamatergically innervated nuclei or competitive and non-competitive NMDA-antagonista administered systemically, counteract parkinsonian symptom in animals.
Appears in Collections:15 Fakultätsübergreifend / Sonstige Einrichtung

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