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http://dx.doi.org/10.18419/opus-9013
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DC Element | Wert | Sprache |
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dc.contributor.author | Bischoff, Annabell | - |
dc.contributor.author | Bayerlová, Michaela | - |
dc.contributor.author | Strotbek, Michaela | - |
dc.contributor.author | Schmid, Simone | - |
dc.contributor.author | Beissbarth, Tim | - |
dc.contributor.author | Olayioye, Monilola A. | - |
dc.date.accessioned | 2017-02-07T14:11:35Z | - |
dc.date.available | 2017-02-07T14:11:35Z | - |
dc.date.issued | 2015 | de |
dc.identifier.issn | 1478-811X | - |
dc.identifier.other | 483213535 | - |
dc.identifier.uri | http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-ds-90304 | de |
dc.identifier.uri | http://elib.uni-stuttgart.de/handle/11682/9030 | - |
dc.identifier.uri | http://dx.doi.org/10.18419/opus-9013 | - |
dc.description.abstract | Background: The growth factor heregulin (HRG) potently stimulates epithelial cell survival and proliferation through the binding of its cognate receptor ErbB3 (also known as HER3). ErbB3-dependent signal transmission relies on the dimerization partner ErbB2, a receptor tyrosine kinase that is frequently overexpressed and/or amplified in breast cancer cells. Substantial evidence suggests that deregulated ErbB3 expression also contributes to the transformed phenotype of breast cancer cells. Results: By genome-wide screening, we identify 43 microRNAs (miRNAs) that specifically impact HRG-induced activation of the PI3K-Akt pathway. Bioinformatic analysis combined with experimental validation reveals a highly connected molecular miRNA-gene interaction network particularly for the negative screen hits. For selected miRNAs, namely miR-149, miR-148b, miR-326, and miR-520a-3p, we demonstrate the simultaneous downregulation of the ErbB3 receptor and multiple downstream signaling molecules, explaining their efficient dampening of HRG responses and ascribing to these miRNAs potential context-dependent tumor suppressive functions. Conclusions: Given the contribution of HRG signaling and the PI3K-Akt pathway in particular to tumorigenesis, this study not only provides mechanistic insight into the function of miRNAs but also has implications for future clinical applications. | en |
dc.language.iso | en | de |
dc.relation.uri | doi:10.1186/s12964-015-0084-z | de |
dc.rights | info:eu-repo/semantics/openAccess | de |
dc.subject.ddc | 570 | de |
dc.title | A global microRNA screen identifies regulators of the ErbB receptor signaling network | en |
dc.type | article | de |
ubs.fakultaet | Energie-, Verfahrens- und Biotechnik | de |
ubs.fakultaet | Fakultätsübergreifend / Sonstige Einrichtung | de |
ubs.institut | Institut für Zellbiologie und Immunologie | de |
ubs.institut | Fakultätsübergreifend / Sonstige Einrichtung | de |
ubs.publikation.seiten | 15 | de |
ubs.publikation.source | Cell communication and signaling 13 (2015), Nr. 5 | de |
ubs.publikation.typ | Zeitschriftenartikel | de |
Enthalten in den Sammlungen: | 04 Fakultät Energie-, Verfahrens- und Biotechnik |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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Bischoff_CCS2015.pdf | 2,47 MB | Adobe PDF | Öffnen/Anzeigen |
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