Please use this identifier to cite or link to this item: http://dx.doi.org/10.18419/opus-9104
Authors: Mai, Bettina
Sommer, Susanne
Hauber, Wolfgang
Title: Dopamine D1/D2 receptor activity in the nucleus accumbens core but not in the nucleus accumbens shell and orbitofrontal cortex modulates risk-based decision making
Issue Date: 2015
metadata.ubs.publikation.typ: Zeitschriftenartikel
metadata.ubs.publikation.seiten: 9
metadata.ubs.publikation.source: International journal of neuropsychopharmacology 18 (2015), issue 10, pyv043
URI: http://elib.uni-stuttgart.de/handle/11682/9121
http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-ds-91219
http://dx.doi.org/10.18419/opus-9104
ISSN: 1469-5111
1461-1457
Abstract: Background: It is well known that brain dopamine (DA) signals support risk-based decision making; however, the specific terminal regions of midbrain DA neurons through which DA signals mediate risk-based decision making are unknown. Methods: Using microinfusions of the D1/D2 receptor antagonist flupenthixol, we sought to explore the role of D1/D2 receptor activity in the rat orbitofrontal cortex (OFC) and core and shell regions of the nucleus accumbens (AcbC and AcbS, respectively) in the regulation of risky choices. A risk-discounting task was used that involves choices between a certain small-reward lever that always delivered 1 pellet or a risky large-reward lever which delivered 4 pellets but had a decreasing probability of receiving the reward across 4 subsequent within-session trial blocks (100%, 50%, 25%, 12.5%). To validate task sensitivity to experimental manipulations of DA activity, we also examined the effects of systemic amphetamine and flupenthixol. Results: Systemic amphetamine increased while systemic flupenthixol reduced risky choices. Results further demonstrate that rats that received intra-AcbC flupenthixol were able to track increasing risk associated with the risky lever but displayed a generally reduced preference for the risky lever across all trial blocks, including in the initial trial block (large reward at 100%). Microinfusions of flupenthixol into the AcbS or OFC did not alter risk-based decision making. Conclusions: Our data suggest that intra-AcbC D1/D2 receptor signaling does not support the ability to track shifts in reward probabilities but does bias risk-based decision making. That is, it increased the rats’ preference for the response option known to be associated with higher risk-related costs.
Appears in Collections:04 Fakultät Energie-, Verfahrens- und Biotechnik

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