Nervous-system-specific carcinogenesis by ethylnitrosourea in the rat: molecular and cellular aspects

Rajewsky, Manfred F.; Augenlicht, Leonard H.; Biessmann, Harald; Goth, Regine; Hülser, Dieter F.; Laerum, Ole D.; Lomakina, L. Ya.

Nervous-system-specific carcinogenesis by ethylnitrosourea in the rat: molecular and cellular aspects

dc.contributor.author	Rajewsky, Manfred F.	de
dc.contributor.author	Augenlicht, Leonard H.	de
dc.contributor.author	Biessmann, Harald	de
dc.contributor.author	Goth, Regine	de
dc.contributor.author	Hülser, Dieter F.	de
dc.contributor.author	Laerum, Ole D.	de
dc.contributor.author	Lomakina, L. Ya.	de
dc.date.accessioned	2011-11-04	de
dc.date.accessioned	2016-03-31T11:44:14Z
dc.date.available	2011-11-04	de
dc.date.available	2016-03-31T11:44:14Z
dc.date.issued	1977	de
dc.date.updated	2012-07-18	de
dc.description.abstract	A lead in the search for cellular determinants favoring neoplastic transformation may be provided by the pronounced tissue specificity of the oncogenic effect of certain carcinogens which do not require enzymatic metabolic activation, i.e., in cases where this specificity cannot be due to tissue differences in the activity of enzymes involved in the formation of the ultimate reactants. A carcinogen that fulfills this condition is the ethylating agent N-ethyl-N-nitrosourea (EtNU). Alkylation of nucleic acid constituents by N-nitroso compounds in relation to mutagenesis and carcinogenesis has received considerable attention recently.	en
dc.identifier.other	368303187	de
dc.identifier.uri	http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-68126	de
dc.identifier.uri	http://elib.uni-stuttgart.de/handle/11682/7796
dc.identifier.uri	http://dx.doi.org/10.18419/opus-7779
dc.language.iso	en	de
dc.rights	info:eu-repo/semantics/openAccess	de
dc.subject.classification	Nitrosoethylharnstoff , Nervensystem , Krebsforschung	de
dc.subject.ddc	570	de
dc.title	Nervous-system-specific carcinogenesis by ethylnitrosourea in the rat: molecular and cellular aspects	en
dc.type	conferenceObject	de
ubs.fakultaet	Fakultätsübergreifend / Sonstige Einrichtung	de
ubs.fakultaet	Fakultät Energie-, Verfahrens- und Biotechnik	de
ubs.institut	Sonstige Einrichtung	de
ubs.institut	Institut für Biomaterialien und biomolekulare Systeme	de
ubs.opusid	6812	de
ubs.publikation.source	Hiatt, H. H. (Hrsg.): Origins of human cancer. B. Cold Spring Harbor : Cold Spring Harbor Laboratory, 1977 (Cold Spring Harbor conferences on cell proliferation 4), S. 709-726	de
ubs.publikation.typ	Konferenzbeitrag	de

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