13 Zentrale Universitätseinrichtungen

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Eine Mutante von Corynebacterium fascians, die die Fähigkeit verloren hat, Benzoesäure zu verwerten
(1988) Ivojlov, V. S.; Karasevic, Jurij N.; Surovceva, E. G.; Pertschi, Ottmar (Übersetzer)
A Corynebacterium fascians strain INMI KIS-9 was obtained. The strain utilized p-fluorbenzoic acid as a carbon source, but could not assimilate its natural analog, benzoic acid because the enzyme catalyzing lactonization of cis, cis-muconic acid was inactivated.
Open Access
Besonderheiten der Transformation und Verwertung von 4-Fluorbenzoesäure durch Corynebacterium fascians
(1987) Ivojlov, V. S.; Karasevic, Jurij N.; Surovceva, E. G.; Pertschi, Ottmar (Übersetzer)
Corynebacterium fascians INMI KIS-1 cannot utilize 4-fluorbenzoic acid since one of the enzyme activities is absent at the terminal steps of 4-FBA preparatory metabolism. Upt to 95% of the fluoride is split off in the course of 4-FBA transformation. The quantity of 4-carboxymethylene butenolide and maleylacetate accumulated in the medium in the process of 4-FBA transformation by C. fascians INMI KIS-1 corresponds, in stochiometrical terms, to the amount of added 4-FBA. This value is far lower (26%) in a C. fascians INMI KIS-9 mutual capable of 4-FBA utilization. Therefore, C. fascians adaptation to 4-FBA should be attributed to the fact that one of the enzyme activities at the terminal steps of 4-FBA preparatory metabolism (maleylacetate reductase) either appears or noticeably rises.