04 Fakultät Energie-, Verfahrens- und Biotechnik

Permanent URI for this collectionhttps://elib.uni-stuttgart.de/handle/11682/5

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    Investigation of tracer gas transport in a new numerical model of lung acini
    (2022) Schmidt, Christoph; Joppek, Christoph; Trinkmann, Frederik; Takors, Ralf; Cattaneo, Giorgio; Port, Johannes
    Obstructive pulmonary diseases are associated with considerable morbidity. For an early diagnosis of these diseases, inert gas washouts can potentially be used. However, the complex interaction between lung anatomy and gas transport mechanisms complicates data analysis. In order to investigate this interaction, a numerical model, based on the finite difference method, consisting of two lung units connected in parallel, was developed to simulate the tracer gas transport within the human acinus. Firstly, the geometries of the units were varied and the diffusion coefficients ( D ) were kept constant. Secondly, D was changed and the geometry was kept constant. Furthermore, simple monoexponential growth functions were applied to evaluate the simulated data. In 109 of the 112 analyzed curves, monoexponential function matched simulated data with an accuracy of over 90%, potentially representing a suitable numerical tool to predict transport processes in further model extensions. For total flows greater than 5 × 10 -4  ml/s, the exponential growth constants increased linearly with linear increasing flow to an accuracy of over 95%. The slopes of these linear trend lines of 1.23 µl -1 ( D  = 0.6 cm 2 /s), 1.69 µl -1 ( D  = 0.3 cm 2 /s), and 2.25 µl -1 ( D  = 0.1 cm 2 /s) indicated that gases with low D are more sensitive to changes in flows than gases with high D .
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    Getting hold of the tobamovirus particle : why and how? Purification routes over time and a new customizable approach
    (2024) Wendlandt, Tim; Britz, Beate; Kleinow, Tatjana; Hipp, Katharina; Eber, Fabian J.; Wege, Christina
    This article develops a multi-perspective view on motivations and methods for tobamovirus purification through the ages and presents a novel, efficient, easy-to-use approach that can be well-adapted to different species of native and functionalized virions. We survey the various driving forces prompting researchers to enrich tobamoviruses, from the search for the causative agents of mosaic diseases in plants to their increasing recognition as versatile nanocarriers in biomedical and engineering applications. The best practices and rarely applied options for the serial processing steps required for successful isolation of tobamoviruses are then reviewed. Adaptations for distinct particle species, pitfalls, and ‘forgotten’ or underrepresented technologies are considered as well. The article is topped off with our own development of a method for virion preparation, rooted in historical protocols. It combines selective re-solubilization of polyethylene glycol (PEG) virion raw precipitates with density step gradient centrifugation in biocompatible iodixanol formulations, yielding ready-to-use particle suspensions. This newly established protocol and some considerations for perhaps worthwhile further developments could serve as putative stepping stones towards preparation procedures appropriate for routine practical uses of these multivalent soft-matter nanorods.
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    Challenges and state of the art in industrial FSW - pushing the limits by high speed welding of complex 3D contours
    (2018) Hoßfeld, Max; Hofferbert, Dave
    Over the last 25 years, Friction Stir Welding (FSW) has been gradually moving from research over first applications into mass production. Today, requirements for consistently high-quality welds occur in parallel with a demand for high throughput as well as production flexibility. This paper gives an insight to the state of the art of industrial FSW mass production, current trends, challenges and market demands as well as the potential of high speed complex contour welding on modern multi-axis FSW machinery with respect to process parameters, material properties, machinery requirements and control algorithms, and methods. The design strategy of complex 3D contours as a chance to maximize efficiency is introduced; challenges of its implementation with respect to the state of the art in FSW are described. This includes the importance of advanced force control methods, fixture design, clamping forces and methodology for sustaining high-quality welds as well as the management of distortions and residual stresses by thermal management and optimization of process parameters. Examples of successful weld performance are described. Steps to be taken that result in high-quality welds, as well as situations to be avoided, are discussed. The publication was written based on results of the DFG project RO 651/16-1 that was carried out at the University of Stuttgart.