Universität Stuttgart
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Item Open Access Counterion effects on the mesomorphic and electrochemical properties of guanidinium salts(2024) Ebert, Max; Lange, Alyna; Müller, Michael; Wuckert, Eugen; Gießelmann, Frank; Klamroth, Tillmann; Zens, Anna; Taubert, Andreas; Laschat, SabineIonic liquid crystals (ILCs) combine the ion mobility of ionic liquids with the order and self-assembly of thermotropic mesophases. To understand the role of the anion in ILCs, wedge-shaped arylguanidinium salts with tetradecyloxy side chains were chosen as benchmark systems and their liquid crystalline self-assembly in the bulk phase as well as their electrochemical behavior in solution were studied depending on the anion. Differential scanning calorimetry (DSC), polarizing optical microscopy (POM) and X-ray diffraction (WAXS, SAXS) experiments revealed that for spherical anions, the phase width of the hexagonal columnar mesophase increased with the anion size, while for non-spherical anions, the trends were less clear cut. Depending on the anion, the ILCs showed different stability towards electrochemical oxidation and reduction with the most stable being the PF6 based compound. Cyclic voltammetry (CV) and density functional theory (DFT) calculations suggest a possible contribution of the guanidinium cation to the oxidation processes.Item Open Access Exploring the growth of refractory metal and sapphire films by thermal laser epitaxy(2024) Majer, Lena N.; Mannhart, Jochen (Prof. Dr.)Item Open Access Development of novel bispecific antibodies for cancer therapy targeting the receptor tyrosine kinases HER4 and EGFR(2024) Kühl, Lennart; Kontermann, Roland E. (Prof. Dr.)In this study, novel mono- and bispecific antibodies targeting the ErbB receptor family members EGFR and HER4 were investigated. Dual targeting of EGFR and HER4 by a bispecific, tetravalent antibody comprising a novel, antagonistic HER4-targeting antibody showed inhibition of proliferation and migration for a HB-EGF-stimulated ovarian cancer cell line. No inhibitory effects in a breast cancer cell line expressing EGFR and HER4 indicated that successful dual targeting does not solely rely on target expression. The complexity of HER4 with its isoforms and their different signaling properties makes HER4 a challenging cancer target that needs further in-depth research. To overcome resistances based on escape mutations located in the epitopes of clinically approved antibodies, novel antagonistic EGFR-targeting antibodies binding to a different epitope were developed. This epitope was mapped to domain III of EGFR and binding to clinically relevant EGFR ectodomain mutations resulted in inhibition of EGFR signaling in stable cell lines used as test systems. Favorable activities in comparison to clinically approved antibodies regarding inhibition of EGFR signaling and proliferation were observed for cancer cell lines expressing the EGFR wildtype. Bispecific T-cell engagers can lead to a T-cell mediated target cell killing independent of intracellular downstream signaling in the cancer cell. One challenge for the applicability of T-cell engagers in solid tumors is to keep the balance between T-cell mediated tumor cell killing and severe side-effects caused by a systemic activation of the immune system. Studies on eleven different eIg-based formats for EGFR-binding T-cell engagers showed that valency, geometry, and size influenced their activity profile. Furthermore, one bivalent and one trivalent, bispecific format were investigated for two novel EGFR-targeting moieties. As these molecules bind to clinically relevant escape mutations located in the ectodomain of EGFR, they are expected to show activity in patients with an acquired resistance to approved EGFR-targeting antibodies. These molecules led to a robust T-cell mediated cytotoxicity of cancer cells expressing EGFR. Additionally, benefits regarding an EGFR-level dependent cytotoxicity were observed for reduced binding to EGFR. An initial in vivo study using surrogate molecules in a syngeneic mouse model showed reduction of tumor growth and prolonged survival for treatment with a trivalent, bispecific T-cell engager comprising a novel EGFR-binding moiety. Taken together, beneficial effects of the novel molecules may contribute to improved therapies for patients with both pre-existing and acquired resistances to EGFR-targeting antibodies.Item Open Access Self-organized structures and excitations in dipolar quantum fluids(2024) Hertkorn, Jens; Pfau, Tilman (Prof. Dr.)Quantum many-body phenomena at a macroscopic scale, such as superfluidity and superconductivity, are rooted in the interplay between microscopic particles, governed by the laws of quantum mechanics. Exploring how this interplay leads to quantum behavior at a large scale allows us to gain a deeper understanding of nature and to discover new quantum phases. An elusive quantum phase in which the frictionless flow of superfluids and the crystal structure of solids coexists - the supersolid - was recently realized with quantum droplets in dipolar Bose-Einstein condensates. In this thesis we investigate self-organized structures, their formation mechanism, and excitations in dipolar quantum fluids created from such Bose-Einstein condensates. We show that the supersolid formation mechanism is driven by density fluctuations due to low-energy roton excitations, leading to a crystal structure of quantum droplets that are immersed in a superfluid background. These roton excitations split into a Goldstone mode and a Higgs amplitude mode, associated to the broken translational symmetry in the supersolid. We investigate the symmetry breaking of dipolar quantum fluids in a range of confinement geometries and establish a comprehensive description of elementary excitations across the superfluid to supersolid droplet phase transition. The droplets are stabilized by an interplay between interactions and the presence of quantum fluctuations. We show how this interplay can be used to find regimes where droplets are immersed in a high superfluid background, allowing for frictionless flow throughout the crystal. Moreover we show that towards higher densities beyond the quantum droplet phase, this interplay leads to several new self-organized structures in the phase diagram of dipolar quantum fluids. We theoretically predict new supersolid honeycomb, amorphous labyrinth, and other phases in oblate dipolar quantum fluids. Finally, we present a new experimental setup for the exploration of self-organized phases in dipolar quantum fluids and which also lays the foundation for the implementation of a quantum gas microscope. The results of this thesis present a complete framework for understanding and creating exotic phases in dipolar quantum fluids. The versatile structure formation, governed by a competition of controllable interactions and the presence of quantum fluctuations, positions dipolar quantum fluids as a model system for exploring self-organized equilibrium in weakly-interacting quantum many-body systems.Item Open Access Interactive visualizations for multivariate weather data on smartwatches(2024) Rohwer, Jakob MoritzDer Markt für Smartwatches wächst schnell und birgt viel Potenzial. Doch der kleine Bildschirm der Geräte stellt Entwickler vor neue Herausforderungen, wenn es um Visualisierung geht. Das gilt insbesondere für komplexere Darstellungen. Für Wetterdaten gibt es viele komplexere Möglichkeiten der Visualisierung, sei es der Temperaturverlauf dargestellt als Diagramm oder die Luftfeuchtigkeit als Fortschrittsanzeige. In dieser Arbeit wird die neue Wetterapplikation WeDaVis vorgestellt, welche neue Arten der Visualisierung für Wetterdaten benutzt. Wie die Ergebnisse unserer Studie gezeigt haben, präferierten die Teilnehmer keine bestimmte Art der Datenrepräsentation, sondern stattdessen hingen die Präferenzen von der Art der Wetterinformation ab. Teilnehmer präferierten die Visualisierungen von WeDaVis bei eher ungewöhnlicheren Daten, wie zum Beispiel der Windstärke oder dem Luftdruck. Textbasierte Darstellungen wurden präferiert, wenn es um bekanntere Informationen, wie die Temperatur, ging. Weitere Ergebnisse der Studie zeigten, dass Möglichkeiten der Interaktion visualisiert werden sollten, denn sonst hatten die Teilnehmer Probleme, diese wahrzunehmen. Da sich die Interessen der Teilnehmer für verschiedene Wetterinformationen unterschieden, sollten Applikationen dementsprechend anpassbar sein, und sollten ungefähr sechs Datenrepräsentationen auf einem Bildschirm anzeigen. Da das Forschungsgebiet der Wetterinformationen relativ neu ist, strebte dieses Projekt an, zu dieser Forschung beizutragen, indem wir versucht haben, eine möglichst effiziente Wetterapplikation zu entwickeln, die auf die Benutzung auf der Smartwatch abgestimmt ist.Item Open Access Experimental investigation of low-frequency sound and infrasound induced by onshore wind turbines(2024) Blumendeller, Esther; Cheng, Po Wen (Prof. Dr.)Climate change has a global impact and is increasingly affecting our environment. This is driving the continuous expansion of renewable energies, with wind energy playing a major role. As wind energy becomes more widespread, an increasing number of people will live near wind turbines in complex terrain. In such scenarios, wind turbines are often positioned at elevated locations, while residents live in valleys. In complex terrain, such as a steep escarpment, local turbulence, wind speed, and direction are strongly influenced by topography, contributing to the complexity of sound propagation or impacts the background noise situation in valleys, for example, due to shielding effects. The operation of wind turbines is associated with both visual and sound-related impact, with sound being generated at various frequencies. There is a growing interest in low-frequency sound and infrasound, characterized by long wavelengths that propagate over considerable distances without significant attenuation. This is in contrast to higher-frequency sound, and might increase the impact of wind turbine sound at residential areas located several hundred meters or a few kilometers away from the wind farm. In the context of complex terrain, this work investigates wind turbines in complex terrain as sources of low-frequency sound and infrasound. The investigations on characterization of sound generation and propagation are based on measurements in the vicinity of two wind farms. Measurements were conducted within four measurement campaigns at two wind farms located close to an escarpment at the Swabian Alb in Southern Germany over a period of about nine month. Acoustic data was obtained in the proximity of the wind turbines and at residential buildings in 1–1.7km distance to the wind farms in municipalities located within a valley. Besides acoustic measurements including the infrasonic frequency range, a comprehensive data set with ground motion data, wind turbine operating data, meteorological data and data from a noise reporting app supports the investigation. Two aspects require analysis: Firstly, the aspect of generation and propagation of wind turbine low-frequency sound and infrasound in complex terrain, and secondly, the relation with annoyance. Results show that sounds within the infrasonic range assigned to the blade passage at the tower are transmitted through the air over distances of 1 km. Low-frequency sounds were found to be amplitude-modulated and were investigated as amplitude modulation. Infrasound and amplitude modulation occurrences were more likely during morning, evening and night hours and during atmospheric conditions with positive lapse rate, vertical wind shear and low turbulence intensity. The occurrence of both infrasound and amplitude modulation was typically observed during rated rotational speed but below-rated power. To allow predictions, a standard prediction method was extended to include the lowfrequency sound and infrasound range and adapted to the measurement data in order to apply it to complex terrain. The sound level difference of the measured data aligns well with the predictions within the frequency range of 8 Hz and 250 Hz. Investigations regarding outdoor-to-indoor sound reductions showed influences from structural resonances and room modes, which depend on the characteristics of the building and the specific room under investigation. Combining acoustic measurements with annoyance reports showed that rated wind turbine operation appears to be a contributing factor in annoyance ratings obtained through a noise reporting app, ranging from “somewhat” to “very” levels. Furthermore, the analysis indicates that varying levels of annoyance at a distance of 1km from the wind farm, both outside and inside buildings, do not correspond to significant differences in the averaged and A-weighted sound pressure levels. Overall, this work contributes to a better understanding of the low-frequency sound and infrasound generated from wind turbines and provides insight into the sound characteristics of measured wind turbine sound at residential locations in complex terrains.Item Open Access Smart ground support equipment : the design and demonstration of robotic ground support equipment for small spacecraft integration and verification(2024) Kottmeier, Sebastian; Wittje, Philipp; Klinkner, Sabine; Essmann, Olaf; Suhr, Birgit; Kirchler, Jan-Luca; Ho, Tra-MiIn order to reduce the costs of integration and verification processes and to optimize the assembly, integration and verification (AIV) flow in the prototype development of small- and medium-sized spacecrafts, an industrial six-axis robot was used as a universal mechanical ground support equipment instead of a tailored prototype specific ground support equipment (GSE). In particular, a robotic platform offers the possibility of embedding verification steps such as mass property determination into the integration process while offering a wider range of ergonomic adaption due to the enhanced number of degrees of freedom compared to a classical static Mechanical GSE (MGSE). This reduces development costs for projects and enhances the flexibility and ergonomics of primarily mechanical AIV operations. In this paper, the robotic MGSE system is described, the operational prospects for in-line verification are elaborated and an example is given showing the possibilities and challenges of its operational use as well as its in-line mass determination capabilities. For this purpose, a method has been developed that allows for the precise measurement of the spacecraft mass using the robot’s existing technology without the need for additional hardware. Subsequent work will extend this to determine the center of gravity and the moments of inertia of the payload on the robotic MGSE.Item Open Access Widersprüche als Potenziale : Konzept für einen Multidialektischen Städtebau am Beispiel großer Quartiersplanungen(2024) Leuter, Harry; Baum, Martina (Prof. Dr.)Die Dissertation untersucht ‚Widersprüche als Potenziale‘ zur Differenzierung von homogenen großen Quartiersplanungen. Philosophische Grundlage ist das dialektische Denken mit der Vermittlung zwischen Widersprüchen als Kernanliegen und der Differenziertheit des Ganzen als Ziel. Die Untersuchung großer Quartiersplanungen in Süddeutschland zeigt, dass die Negierung von Widersprüchen in verschiedenen Dimensionen zu einer ungewollten Widerspruchsfreiheit in der räumlichen Ausprägung der Quartiere führt. Statt Widersprüche zu negieren, wird in der Arbeit ein aktiver Umgang mit den Widersprüchen verfolgt und als Research by Design getestet. Daraus wird ein Konzept entwickelt für einen Städtebau, der dialektisch vermittelt zwischen einer Vielzahl an Widersprüchen innerhalb sowie zwischen unterschiedlichen Betrachtungs- und Maßstabsebenen - einen Multidialektischen Städtebau.Item Open Access Long wave approximation over and beyond the natural time scale(2024) Hofbauer, Sarah; Schneider, Guido (Prof. Dr.)Item Open Access Analyzing and characterizing spaceborne observation of water storage variation : past, present, future(2024) Saemian, Peyman; Sneeuw, Nico (Prof. Dr.-Ing.)Water storage is an indispensable constituent of the intricate water cycle, as it governs the availability and distribution of this precious resource. Any alteration in the water storage can trigger a cascade of consequences, affecting not only our agricultural practices but also the well-being of various ecosystems and the occurrence of natural hazards. Therefore, it is essential to monitor and manage the water storage levels prudently to ensure a sustainable future for our planet. Despite significant advancements in ground-based measurements and modeling techniques, accurately measuring water storage variation remained a major challenge for a long time. Since 2002, the Gravity Recovery and Climate Experiment (GRACE) and its successor GRACE Follow-On (GRACE-FO) satellites have revolutionized our understanding of the Earth's water cycle. By detecting variations in the Earth's gravity field caused by changes in water distribution, these satellites can precisely measure changes in total water storage (TWS) across the entire globe, providing a truly comprehensive view of the world's water resources. This information has proved invaluable for understanding how water resources are changing over time, and for developing strategies to manage these resources sustainably. However, GRACE and GRACE-FO are subject to various challenges that must be addressed in order to enhance the efficacy of our exploitation of GRACE observations for scientific and practical purposes. This thesis aims to address some of the challenges faced by GRACE and GRACE-FO. Since the inception of the GRACE mission, scholars have commonly extracted mass changes from observations by approximating the Earth's gravity field utilizing mathematical functions termed spherical harmonics. Various institutions have already processed GRACE(-FO) data, known as level-2 data in the GRACE community, considering the constraints, approaches, and models that have been utilized. However, this processed data necessitates post-processing to be used for several applications, such as hydrology and climate research. In this thesis, we evaluate various methods of processing GRACE(-FO) level-2 data and assess the spatio-temporal effect of the post-processing steps. Furthermore, we aim to compare the consistency between GRACE and its successor mission, GRACE-FO, in terms of data quality and measurement accuracy. By analyzing and comparing the data from these two missions, we can identify any potential discrepancies or differences and establish the level of confidence in the accuracy and reliability of the GRACE-FO measurements. Finally, we will compare the processed level-3 products with the level-3 products that are presently accessible online. The relatively short record of the GRACE measurements, compared to other satellite missions and observational records, can limit some studies that require long-term data. This short record makes it challenging to separate long-term signals from short-term variability and validate the data with ground-based measurements or other satellite missions. To address this limitation, this thesis expands the temporal coverage of GRACE(-FO) observations using global hydrological, atmospheric, and reanalysis models. First, we assess these models in estimating the TWS variation at a global scale. We compare the performance of various methods including data-driven and machine learning approaches in incorporating models and reconstruct GRACE TWS change. The results are also validated against Satellite Laser Ranging (SLR) observations over the pre-GRACE period. This thesis develops a hindcasted GRACE, which provides a better understanding of the changes in the Earth's water storage on a longer time scale. The GRACE satellite mission detects changes in the overall water storage in a specific region but cannot distinguish between the different compartments of TWS, such as surface water, groundwater, and soil moisture. Understanding these individual components is crucial for managing water resources and addressing the effects of droughts and floods. This study aims to integrate various data sources to improve our understanding of water storage variations at the continental to basin scale, including water fluxes, lake water level, and lake storage change data. Additionally, the study demonstrates the importance of combining GRACE(-FO) observations with other measurements, such as piezometric wells and rain-gauges, to understand the water scarcity predicament in Iran and other regions facing similar challenges. The GRACE satellite mission provides valuable insights into the Earth's system. However, the GRACE product has a level of uncertainty due to several error sources. While the mission has taken measures to minimize these uncertainties, researchers need to account for them when analyzing the data and communicate them when reporting findings. This thesis proposes a probabilistic approach to incorporate the Total Water Storage Anomaly (TWSA) data from GRACE(-FO). By accounting for the uncertainty in the TWSA data, this approach can provide a more comprehensive understanding of drought conditions, which is essential for decision makers managing water resources and responding to drought events.