Please use this identifier to cite or link to this item: http://dx.doi.org/10.18419/opus-1143
Authors: Effenberger, Franz
Hopf, Martin
Ziegler, Thomas
Hudelmayer, Jochen
Title: Darstellung O-geschützter (R)-2-Hydroxyaldehyde und ihre Hydrocyanierung
Other Titles: Synthesis of O-protected (R)-2-hydroxy aldehydes and their hydrocyanation
Issue Date: 1991
metadata.ubs.publikation.typ: Zeitschriftenartikel
metadata.ubs.publikation.source: Chemische Berichte 124 (1991), S. 1651-1659. URL http://dx.doi.org./10.1002/cber.19911240728
URI: http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-43953
http://elib.uni-stuttgart.de/handle/11682/1160
http://dx.doi.org/10.18419/opus-1143
Abstract: The synthesis of O-silyl- and O-benzyl-protected (R)-2-hydroxy aldehydes (R)-6 from (R)-2-hydroxy carboxylic acids (R)-1 is described. While attempts for their diastereoselective hydrocyanation with hydrocyanic acid and (R)-oxynitrilase as catalyst have not been successful, the cyano silylation with trimethylsilyl cyanide occurred diastereoselectively with a ratio of 81 : 19 preferring the threo form without racemization at C-2 of the 2-hydroxy aldehyde.
Appears in Collections:03 Fakultät Chemie

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