1. OPUS
  2. Universität Stuttgart
  3. 03 Fakultät Chemie
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dc.contributor.authorIcik, Esra-
dc.contributor.authorJolly, Anthony-
dc.contributor.authorLöffler, Paul-
dc.contributor.authorAgelidis, Nektarios-
dc.contributor.authorBugdayci, Bakiye-
dc.contributor.authorAltevogt, Luca-
dc.contributor.authorBilitewski, Ursula-
dc.contributor.authorBaro, Angelika-
dc.contributor.authorLaschat, Sabine-
dc.date.accessioned2024-03-01T15:29:04Z-
dc.date.available2024-03-01T15:29:04Z-
dc.date.issued2020de
dc.identifier.issn1099-0690-
dc.identifier.issn1434-193X-
dc.identifier.other1882509048-
dc.identifier.urihttp://nbn-resolving.de/urn:nbn:de:bsz:93-opus-ds-140057de
dc.identifier.urihttp://elib.uni-stuttgart.de/handle/11682/14005-
dc.identifier.urihttp://dx.doi.org/10.18419/opus-13986-
dc.description.abstractThree N‐Boc‐protected amino acids, l‐serine, l‐aspartic, and l‐glutamic acid, were either converted into their methyl azidoalkanoates or various alkynes via Bestmann‐Ohira strategy or via reaction with propargylamine and propargyl bromide, respectively. The Cu‐catalyzed click reaction provided a library of amino acid based triazoles, which were further N‐methylated to triazolium iodides or deprotected and precipitated as free amino acid triazole dihydrochlorides. The biological properties of all derivatives were investigated by cytotoxicity assay (against L929 mouse fibroblasts) and broth microdilution method (E. coli ΔTolC and S. aureus). First results reveal complete inactivity for triazolium iodides with cell viabilities and microbial growths nearly 100 %, indicating them as possible analogs of advanced glycation endproducts (AGEs).en
dc.description.sponsorshipMinisterium für Wissenschaft, Forschung und Kunst Baden‐Württembergde
dc.description.sponsorshipCarl‐Zeiss‐Stiftungde
dc.description.sponsorshipBaden‐Württemberg Stiftungde
dc.description.sponsorshipProjekt DEALde
dc.language.isoende
dc.relation.uridoi:10.1002/ejoc.202000811de
dc.rightsinfo:eu-repo/semantics/openAccessde
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/de
dc.subject.ddc540de
dc.titleSynthesis and biological evaluation of a library of AGE‐related amino acid triazole crosslinkersen
dc.typearticlede
dc.date.updated2023-11-14T05:53:35Z-
ubs.fakultaetChemiede
ubs.fakultaetFakultätsübergreifend / Sonstige Einrichtungde
ubs.institutInstitut für Organische Chemiede
ubs.institutFakultätsübergreifend / Sonstige Einrichtungde
ubs.publikation.seiten5368-5379de
ubs.publikation.sourceEuropean journal of organic chemistry 2020 (2020), S. 5368-5379de
ubs.publikation.typZeitschriftenartikelde
Enthalten in den Sammlungen:03 Fakultät Chemie

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