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http://dx.doi.org/10.18419/opus-13986
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DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Icik, Esra | - |
dc.contributor.author | Jolly, Anthony | - |
dc.contributor.author | Löffler, Paul | - |
dc.contributor.author | Agelidis, Nektarios | - |
dc.contributor.author | Bugdayci, Bakiye | - |
dc.contributor.author | Altevogt, Luca | - |
dc.contributor.author | Bilitewski, Ursula | - |
dc.contributor.author | Baro, Angelika | - |
dc.contributor.author | Laschat, Sabine | - |
dc.date.accessioned | 2024-03-01T15:29:04Z | - |
dc.date.available | 2024-03-01T15:29:04Z | - |
dc.date.issued | 2020 | de |
dc.identifier.issn | 1099-0690 | - |
dc.identifier.issn | 1434-193X | - |
dc.identifier.other | 1882509048 | - |
dc.identifier.uri | http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-ds-140057 | de |
dc.identifier.uri | http://elib.uni-stuttgart.de/handle/11682/14005 | - |
dc.identifier.uri | http://dx.doi.org/10.18419/opus-13986 | - |
dc.description.abstract | Three N‐Boc‐protected amino acids, l‐serine, l‐aspartic, and l‐glutamic acid, were either converted into their methyl azidoalkanoates or various alkynes via Bestmann‐Ohira strategy or via reaction with propargylamine and propargyl bromide, respectively. The Cu‐catalyzed click reaction provided a library of amino acid based triazoles, which were further N‐methylated to triazolium iodides or deprotected and precipitated as free amino acid triazole dihydrochlorides. The biological properties of all derivatives were investigated by cytotoxicity assay (against L929 mouse fibroblasts) and broth microdilution method (E. coli ΔTolC and S. aureus). First results reveal complete inactivity for triazolium iodides with cell viabilities and microbial growths nearly 100 %, indicating them as possible analogs of advanced glycation endproducts (AGEs). | en |
dc.description.sponsorship | Ministerium für Wissenschaft, Forschung und Kunst Baden‐Württemberg | de |
dc.description.sponsorship | Carl‐Zeiss‐Stiftung | de |
dc.description.sponsorship | Baden‐Württemberg Stiftung | de |
dc.description.sponsorship | Projekt DEAL | de |
dc.language.iso | en | de |
dc.relation.uri | doi:10.1002/ejoc.202000811 | de |
dc.rights | info:eu-repo/semantics/openAccess | de |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | de |
dc.subject.ddc | 540 | de |
dc.title | Synthesis and biological evaluation of a library of AGE‐related amino acid triazole crosslinkers | en |
dc.type | article | de |
dc.date.updated | 2023-11-14T05:53:35Z | - |
ubs.fakultaet | Chemie | de |
ubs.fakultaet | Fakultätsübergreifend / Sonstige Einrichtung | de |
ubs.institut | Institut für Organische Chemie | de |
ubs.institut | Fakultätsübergreifend / Sonstige Einrichtung | de |
ubs.publikation.seiten | 5368-5379 | de |
ubs.publikation.source | European journal of organic chemistry 2020 (2020), S. 5368-5379 | de |
ubs.publikation.typ | Zeitschriftenartikel | de |
Enthalten in den Sammlungen: | 03 Fakultät Chemie |
Dateien zu dieser Ressource:
Datei | Beschreibung | Größe | Format | |
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EJOC_EJOC202000811.pdf | 1,65 MB | Adobe PDF | Öffnen/Anzeigen |
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