Please use this identifier to cite or link to this item: http://dx.doi.org/10.18419/opus-6916
Authors: Hauber, Wolfgang
Schmidt, Werner J.
Title: The NMDA antagonist dizocilpine (MK-801) reverses haloperidol-induced movement initiation deficits
Issue Date: 1990
metadata.ubs.publikation.typ: Zeitschriftenartikel
metadata.ubs.publikation.source: Behavioural Brain Research 41 (1990), S. 161-166. URL http://dx.doi.org./10.1016/0166-4328(90)90151-4
URI: http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-39703
http://elib.uni-stuttgart.de/handle/11682/6933
http://dx.doi.org/10.18419/opus-6916
Abstract: The present study shows that systemic dopamine receptor blockade impaired movement initiation of rats, trained in a simple reaction time task for rapid initiation of locomotion in response to a combined optic/acoustic cue. Reaction time, movement time and the accelerative force were recorded for each initiation of locomotion. Results indicate a dose-related increase of reaction time following systemic administration of haloperidol (0.1, 0.15, 0.3 mg/kg i.p.). Measures derived from resulting force-time patterns showed a haloperidol-induced decrease (0.15 mg/kg i.p.) of the mean rate of force development, indicating a decreased initial acceleration. These effects were reversed by systemic co-administration of dizocilpine (MK-801) (0.08 mg/kg i.p.), a selective non-competitive N-methyl-d-aspartate (NMDA) antagonist. The haloperidol-induced movement initiation deficits in this task are in part comparable to akinesia seen in Parkinson's disease and their reversal by dizocilpine has implications for the treatment of this disease.
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